01:119:116 Lecture Notes - Lecture 26: Antigen-Presenting Cell, Disulfide, Clonal Selection

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L26 immunity ii: adaptive immunity, timing- takes a few days to mobilize. 1: 2 types involved in adaptive immunity. Both originate from stem cells in bone marrow. Some remain in bone marrow & mature b cells. Binds to antigen receptor (b or t cell) Each b cell & t cell displays specificity for a specific epitope. B cells: y-shaped receptors- 4 polypeptide chains, 2 identical heavy chains, 2 identical light chains, disulfide bridge- link chains, transmembrane region- near one end of each heavy chain. Anchors receptors in b cell plasma membrane: constant region- portions of heavy & light chains. Aa sequence varies very little among different b cells: variable region- within two tips. Each is a binding site of an antigen. Each receptor has 2 identical antigen-binding sites: b cell activation, when no pathogen present- b cells inactive, activation begins when a b cell antigen receptor binds to an antigen.

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