NROSCI 1030 Lecture Notes - Lecture 10: Tardive Dyskinesia, Myoclonus, Chorea
Document Summary
Hu(cid:374)ti(cid:374)gto(cid:374)"s chorea: george huntington ide(cid:374)tified these people (cid:449)ith a(cid:271)(cid:374)or(cid:373)al (cid:373)o(cid:448)e(cid:373)e(cid:374)ts as hu(cid:374)ti(cid:374)gto(cid:374)"s i(cid:374) (cid:1005)(cid:1012)(cid:1011)5, three main characteristics, heritable, chorea, dementia. It has complete penetrance if you have the gene you get the disease. If o(cid:374)e pare(cid:374)t has hu(cid:374)ti(cid:374)gto(cid:374)"s there is a 5(cid:1004)% the (cid:272)hild (cid:449)ill ha(cid:448)e it. I(cid:374) (cid:1005)(cid:1013)53, a hu(cid:374)ti(cid:374)gto(cid:374)"s ge(cid:374)e (cid:449)as isolated it 15 chromosome #4. Lots of reactive depression, classical unipolar depression depression occurs before chorea onset: 10% have psychosis that looks like schizophrenia. In pa, 80-(cid:1013)(cid:1004)% of da lost (cid:271)efore sy(cid:373)pto(cid:373)s (cid:271)ut i(cid:374) hu(cid:374)ti(cid:374)gto(cid:374)"s (cid:272)horea occurs as degenerative starts before there is striatal degeneration at all there are chorea symptoms. In pa, anti-cholinergic and l-dopa treat it while anti-psychotics make it worse; in ha, anti-cholinergic and l-dopa make it worse while anti-psychotics decrease chorea. In pa, it starts with akinesia while in ha it starts with hyperkinesia (both end with akinesia)
