BIOL 230W Lecture Notes - Lecture 30: Nanofiber, Cell Adhesion, Cytoskeleton
Document Summary
Biol 230w lecture 30 engineering of ecm. Topographic reaction: reaction to surface landscape: grooves, ridges. Nanoscale alterations in topography elicit diverse cell behavior: due to interactions between cell and ecm, can alter cell adhesion, motility, orientation, cytoskeletal arrangement, and signaling pathways. All cells will not respond in the same way to engineered surfaces. Mechanical properties (how it is made: scientists used to only focus on this aspect. Nanoscale details (including signaling molecules: focusing on incorporating this component as well to make best possible organs. Incorporating both factors yields the greatest results for organ regeneration. Benefits of using amphiphilic method to synthesize ecm: head region contains rgd motifs that bind integrins, gives it the same function. Ecm can provide directional and temporal cues for growth, migration, and development: based on biological cues. Cryptic binding sites: may be revealed during cell damage, may be revealed during different stages of development, alter cell signaling events.
