BIOL 230W Lecture Notes - Lecture 28: Wound Healing, Cell Migration, Peptide
Document Summary
Biol 230w lecture 28 the extracellular matrix. Biofilms: bacteria living in ecm: can contribute to antibiotic resistance. Ecm helps with adhesion and cell signaling. Adhesion is a mechanical function: cell to ecm attachment, mechanical support, motility. Integrate cells into tissues: provide positional information, aid development. Cell to ecm interactions are called focal adhesions. Proteoglycans: proteins with sugar chains: have the ability to attract water. Proteins: fibrous (collagen) vs. adhesive (lamin, fibronectins: bind to integral membrane proteins. Ligands of integrin are diverse and many contain rgd peptide motif (arg-gly-asp: part of ligand, not integrin. Mutations in primary structure will affect motif function. Fibronectin is a common ligand for integrins. Proteins interact in the ecm to form fibrils that make complex web of ecm. Functions in cell migration and wound repair. Mutations are embryotic lethal: critical for development. Produced in cell as inactive form and secreted to ecm.
