BIOL 230W Lecture Notes - Lecture 27: Reactive Oxygen Species, Voltage-Dependent Anion Channel, Acetyl-Coa
Document Summary
Biol 230w lecture 26 after glycolysis. Pyruvate glucose: gluconeogenesis, promote enzyme. Acetyl coa etc: krebs cycle. Some tissues can only use glucose: brain. Only certain cells can undergo gluconeogenesis: liver. Energy expensive but gain more and more atp. Steps 1, 3, 10 have large negative delta g values. Glycolysis uses different enzymes than gluconeogenesis for the irreversible steps: glycolysis: hexokinase, phosphofructokinase, pyruvate kinase, gluconeogenesis: glucose 6 phosphate, fructose 1,6 biphosphate, pep carboxylkinase, pyruvate carboxylkinase. Steps with large negative delta g values have different enzymes. Same enzymes at all other steps: equilibrium, reactions can be reversed. Many regulators inhibit one side, while activating another: prevents the two pathways from being on at the same time. Glycolysis inhibited by high atp levels: don"t need more glucose/atp, store for later. Electrons from fadh2 result in lower production of atp than electrons from nadh: enter chain later.
