BIOL 230W Lecture Notes - Lecture 19: Tumor Suppressor Gene, Mitogen, Cyclin E
Document Summary
Differentiated cells found in g0: cells that have taken on a specific function (like neurons) If triggered by mitogen, cell enters into g1. A cell in g1 will progress to s if environmental conditions are favorable. Both types of proteins are transcribed and translated via signaling pathways. P53 guardian of the genome : activated during cell stress (like dna damage, upregulates ink/kip, tumor suppressor gene. Balancing act between p proteins and kinases (cdk: kinase activities outweighs p protein activity progression. No signals indicating dna damage or stress. P protein activity outweighs kinase activity inhibition. P16 and p21 are inhibitors of cdk4 and cdk6. G1 s transition: g1 s requires cdk2 and cyclin e, progression through s requires cyclin a. S phase progression: cyclin a-cdk2 upregulates dna-dependent dna polymerase function during s phase. Cell proceeds to mitosis if dna is undamaged and environment is favorable.
