BIOL-UA 21 Lecture Notes - Lecture 27: Biome, Rna Interference, Crispr
22 Dec 2016
School
Department
Course
Professor
Document Summary
Lecture 27: systems biology: system: interactions between components. Protein-metabolite: transcription factor binding to regulatory region. Post transcriptional regulation. micrornas control translation by binding to mrna. Sigma factor binding to rna pol: network analysis of interactions between components: Network is made up of nodes, and edges that connect them. The degree is the number of edges a node has. Random networks contains nodes with randomly placed connections. Scale-free network contains hubs with a very high number of links. Molecules involved in burning food for energy (nodes) Random networks are fractured by most node failures. Scale free networks are robust to most node failures, but if a hub fails, the attack is lethal: signi cance of scale-free networks in biology: Biological organisms are unaffected by most random mutations, but mutations affecting hubs are lethal. p53: protein-protein interactome: To understand the network of physical interactions between all proteins in the cell that carry out the cellular functions encoded in the genome.
