ENVS 4210 Lecture Notes - Lecture 10: Histone Deacetylase, Tumor Suppressor Gene, Dna Methyltransferase
Document Summary
What cancers have increased substantially in the us melanoma, nhl, testicular, brain, and thyroid. Dna methylation add a ch3- to cytosine; affects expression of the dna; aka may silence a tumor suppressor gene. Dna + dnmt (methyl trasnferase) --> silences tumor supressor genesdna + dnmt (methyl trasnferase) --> silences tumor supressor genes histone epigenetics add an acetyl group to the histone; dna is usually more accessible. Histone + coch3 ---> hdac (deactylase) ---> histone. Silences tumor suppressor activity micrornas molecules that regulate expression post-transcriptionally. Diet and dna methylation high fat diets, red meats, processed meats, and other foods can cause dna methylation anticancer nutrients blueberries, fruits, veggies. Ir affects what cellular proccesses gene expression, mitochondrial function, nucleotide base damage and single and double strand. Rigi alters dna in what way epigenetic gap junctions cell-to-cell channel spanning two plasma membranes; result from the bridging of two half channels/connexons.
