IBIO 425 Lecture Notes - Lecture 20: Cell Adhesion Molecule, Intermediate Filament, Hemidesmosome
Document Summary
Histology the study of tissue structure and function. Extracellular matrix an extracellular material that is synthesized and secreted by the cells of a tissue. Membrane-spanning proteins responsible both for cell junctions and for transient cell adhesions. Gap junctions allow communication, very simple, connexins are the proteins. Tight junctions occluding junctions that restrict the movement of material between the two cells it connects, claudins and occludins are the proteins. Attach cells to each other or to extracellular matrix. Adherens junctions link actin fibers in adjacent cells together (cell-cell) in anchoring junctions. Desmosomes attach to intermediate filaments of the cytoskeleton - strongest cell-cell junctions. Hemidesmosomes strong junctions that anchor intermediate fibers of the cytoskeleton to matrix. Focal adhesions tie intracellular actin fibers to different matrix proteins cell functional unit of living organisms. The space that is surrounded by the tissue wall of hollow organs is known as the lumen.
