BIOL 4087 Lecture 9: fb91ebb2a8575647ddc0080ea37cef85
Document Summary
Chapter 12 biosignaling: general features, g proteins coupled receptors, (cid:451)-adrenergic receptor, receptor tyrosine kinases insulin receptor, receptor guanylyl cyclase, oncogenes. *fig 12-1: specificity, signal binds specifically to its complementary receptor (low. G-protein coupled receptors (gpcr, serpentine, ttm: g-protein = guanine nucleotide binding protein, 3 essential components of gpcrs, plasma membrane receptor, effector enzyme in plasma membrane that generates a intracellular 2nd messenger, g protein that activates effector enzyme. Adrenergic receptor epinephrine (adrenalin: (cid:451)-adrenergic receptor (is a gpcr, *fig 12-3, 12-4, 14-5. This activates gs (stimulatory g protein) to bind gtp and release. Gdp: fig 12-5 binds gtp, heterotrimeric, activation of gs, gs- gdp(cid:451)(cid:452) + gtp (activation) gtp(cid:451)(cid:452) + gdp gs- gtp. + (cid:451)(cid:452: off switch: gtp + h2o gdp + pi, gdp + (cid:451)(cid:452) gdp(cid:451)(cid:452, active gtp bound, inactive gdp bound, 3. Protein kinase a: ser-oh or thr-oh + atp protein-po42- + adp, example of reversible covalent modification, adding phosphate to protein can modify its function.
