FNU 203 Lecture Notes - Lecture 9: Impaired Glucose Tolerance, Gestational Diabetes, Reactive Hypoglycemia

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1 Nov 2017

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6 carbon glucose--> 2 pyruvate (3 cs each) Produces 2 atp for each glucose split and high energy electrons. Pyruvate combines with 2 c molecule and coenzymea to make acetyl coa. One c is removed at a time to produce 2 atp for every 1 glucose molecule; also releases electrons. Electrons come in, are shuttled down the proteins in the chain and their energy moves hydrogens across the cell membrane to create a concentration gradient of charges. As they move across, a phosphorous molecule is added to adp to make atp. Oxaloacetate- comes from carbohydrate sources: when cho stores are low, cho is spared-- acetyl coa cannot enter the kreb"s cycle, when we use ketones for energy source, increase the acidity of the body. Glycogenic amino acids- can be used & converted into glucose. Ketosis- ketones can fuel the heart, liver, and even brain.

Related Questions

Which of the following is not a net product of the citric acid cycle for each molecule of pyruvate generated in glycolysis?

Select one:

a. 1 ATP (GTP)

b. 1 acetyl coA

c. 3 NADH

d. 1 FADH2

Question 2

Which of the following is NOT an end product for an acetyl group that enters the citric acid cycle?

Select one:

a. ATP

b. NADH

c. FADH2

d. oxaloacetate

Question 3

Once they have been processed through the citric acid cycle, the acetyl-CoA molecules from a single glucose molecule produce:

Select one:

a. 2 ATP, 6 NADH, 4 CO₂.

b. 6 NADH, 6 GTP.

c. 6 FADH₂, 2 ATP, 6 CO₂.

d. 6 GTP, 6 FADH₂.

e. 4 CO₂, 6 FADH₂, 2 ATP.

Question 4

The products of the citric acid cycle breaking down 2 acetyl-CoA include 2 ATP (converted from GTP), 6 NADH and 2 FADH2.

Select one:

True

False

1) The complete catabolism of glucose results in the generation of ___________ ATP.

	1.	29
	2.	100
	3.	20
	4.	50

2) The presence of _____________________ is a determinant factor on whether pyruvate continues its metabolism into the Krebs cycle.

3) As humans we breath in air that contains oxygen and breath out carbon dioxide . The oxygen we consume it is used in the metabolism of glucose in the ________________________.

electron transport chain as an acceptor of electrons

anaerobic respiration

citric acid cycle

4.conversion of pyruvate to acetyl-CoA

4) A glucose molecule can generate energy, but only if sufficient amount of energy is invested to initiate the chemical reactions that are involved in the catabolism of the glucose molecule.

True

False

5) The ___________________ of glycogen from individual/separate molecults of glucose is an ___________________ reaction.

	1.	breakdown, endergonic
	2.	breakdown, exergonic
	3.	synthesis, endergonic
	4.	synthesis, exergonic

1. Integrated metabolism

A. A molecule of glucose that you eat can eventually be transformed into part of a fatty acid that you store. Circle the pathways/cycles below that are part of this overall flow of carbon atoms. Cross out any that are not.

Gluconeogenesis, beta-oxidation, citric acid cycle, glycolysis, urea cycle, fatty acid synthesis

B. Trace the metabolic path of this glucose molecule through the enzymes it encounters along the way to being made into fat. Write all the enzymes in the list below into the proper places in the figure below. If the enzyme is not used, write its name in a ânot used" column. If it is used, write the enzyme in the order that the carbon atoms from glucose encounter the enzymes.

Pyruvate dehydrogenase, fumarase, aldolase, lactate dehydrogenase, pyruvate kinase, acetyl CoA carboxylase, fatty acid synthase, hexokinase, carnitine acyltransferase, ATP synthase

B. What is the minimum number of glucose molecules that would be necessary to be the carbon source for synthesis of a 16-carbon fatty acid through this pathway?

C. How many net glucose can be made from one molecule of a 16-carbon fatty acid?

2. Describe each cycle/transport system (compounds, compartments, tissues) and explain its purpose:

A. citrate transport system

B. Cori cycle

C. glucose/alanine cycle

Explain the logic of these pathway regulations:

A. Phosphofructokinase, not hexokinase, is the main regulation site of glycolysis.

B. SuccinylCoA inhibits the entry of acetyl CoA into the citric acid cycle.

C. NADH inhibits pyruvate dehydrogenase.

D. Citrate inhibits the citric acid cycle and activates acetyl-CoA carboxylase.

E. Insulin leads to activation of glycogen synthase.

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FNU 203 Lecture Notes - Lecture 9: Impaired Glucose Tolerance, Gestational Diabetes, Reactive Hypoglycemia

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