MATH 190 Lecture Notes - Lecture 27: Amyloid Precursor Protein, Longitudinal Study, Clustering Coefficient
Document Summary
Gogtay: mapping gray matter development: implications for typical development and vulnerability to psychopathology. Aim: overview of normal grey matte (gm) development in the human brain & how knowledge can be applied to understand gm changes in neuropsychiatric illnesses across life span (e. g. schizophrenia, bipolar illness) Earlier studies: use lobar volumes of specific anatomical regions showed how different lobes of the brain matured at different rates. Suitable for mapping growth rates for different structures tbm provided among the best results in terms of longitudinal precision. Non-linear changes: gm follows an inverted u-shaped trajectory in frontal, parietal and temporal lobe: pre-pubertal increased followed by post-pubertal loss. Increased synaptic pruning during adolescence and early adulthood & intra-cortical myelination . Gm reduction: compared to white matter development: increases linear until mid-forties. Heterogeneity: gm development is heterogeneous across major lobes. Sex differences: females peaks around 1-2 years earlier than males. Problem: current mri resolution cannot establish the exact cellular processes underlying gm loss.
