RIU 330 Lecture Notes - Lecture 79: Peritonitis, Esophageal Atresia, Intrinsic Factor

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Multifactorial disorders (e. g. , peptic ulcer, inflammatory bowel disease) Most tumors histologically classified as squamous cell carcinomas. Clinically presents as swelling of glands or xerostomia. May affect major or minor salivary glands. Developmental abnormalities: atresia with or without esophageal- tracheal fistula. Accounts for 4% of all cancers: 8000 cases per year in u. s. Higher incidence in asia and africa than in u. s. and europe. Squamous cell carcinoma in upper or lower esophagus. Adenocarcinoma in lower esophagus developing in barrett"s esophagus. Bleeding: acute with hematemesis or chronic with melena. Systemic consequences: iron deficiency anemia caused by chronic blood loss, vitamin b12 malabsorption- related megaloblastic anemia. Acute (erosive): stress, shock, food, exogenous chemicals, drugs. Chronic atrophic gastritis with and without intestinal metaplasia. Mucosal barrier defects: stress, shock, nsaids, smoking reduce resistance. Helicobacter pylori : found in most patients. Hemorrhage (most common): hematemesis, melena, iron deficiency anemia. Benign epithelial tumors: polyps (e. g. , hyperplastic, tubular, villous)

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