MCB 3020C Lecture Notes - Lecture 31: Mhc Class Ii, Human Leukocyte Antigen, Mhc Class I
Document Summary
Class i and class ii mhc proteins: major histocompatibility complex (mhc) molecules are also called human leukocyte antigens (hlas) in humans. Mhc class i are found on all nucleated cells. Mhc class ii proteins are found on professional antigen-presenting cells, such as dendritic cells, macrophages, and b cells: present the internalized antigen to cd4+ t cells, activate helper t cells, receive t cell help. Polymorphism, polygeny, and the immune barrier to tissue transplantation: mhc molecules are polymorphic, meaning they have many, many different alleles for each of the genes. Mhc genes and proteins, which is why organ donations between family members have a greater chance of success. Tcrs of a given t cell bind only to mhc structure. T cells do not interact with a foreign antigen unless it is presented in the context of an. 27. 7 t cell receptors: proteins, genes, and diversity. Inappropriate immune response that results in host damage.