MCB 3020C Lecture Notes - Lecture 13: Mycobacterium Tuberculosis, Antimicrobial Resistance, Viral Disease
Document Summary
Antibiotics are antimicrobials naturally produced by microbes: kill or inhibit bacterial growth, target essential molecular processes. Persistence: population of antibiotic-sensitive bacteria produces rare cells that are transiently tolerant to multiple antibiotics. Virus: genetic element that cannot replicate independently of a living (host) cell. Virus particle (virion): extracellular form of a virus: exists outside host and facilitates transmission from one host cell to another. Replication/reproduction occurs only upon infection (entry into host cell) Viruses can be classified on the basis of the hosts they infect: bacterial viruses, archaeal viruses, animal viruses, plant viruses, other viruses. Viruses come in many shapes and sizes: most viruses are smaller than prokaryotic cells; range from 0. 02 to 0. 3um. Virion structure: capsomere: individual protein molecule arranged in a precise and highly repetitive pattern around the nucleic acid making up the capsid, capsids can be put together through self-assembly (spontaneous) or require host cell folding assistance. Phases of viral replication in a permissive (supportive) host: 1.
