HLTH 210 Lecture Notes - Lecture 15: Cruciferous Vegetables, Resveratrol, Bioavailability
7 May 2018
School
Department
Course
Professor
“Integrative+Medicine+in+Cancer+Survivorship+and+Prevention”-+Dr.+Omer+Kucuk+
• Connection+between+physical+activity,+diet,+and+health+
• 30+minutes+of+activity+has+been+shown+to+lower+the+risk+of+and+prevent+cancer+and+
Alzheimer’s+
• using+diet+and+exercise+to+prevent+and+treat+disease,+and+the+adverse+effects+of+disease+
treatments+can+save+money+
• there+are+14+million+cancer+survivors++
• NCCIH+has+long+term+goals+surrounding+integrative+medicine+(physical+activity,+diet,+
mind-body+approaches)+and+the+government+is+funding+research+in+this+area+
• Mind-body+approach:+yoga+
o Studies+have+shown+that+yoga+(&+meditation):+boosts+immune+system+by+making+
epigenetic+changes+that+impact+gene+expression,+provides+improved+response+to+
environmental+stress+(stress,+depression,+anxiety,+inflammation)+
o In+breast+cancer+patients+specifically:+lowers+depression+and+fatigue,+increases+
vitality+
• Exercise+provides+many+health+benefits+
o Colon+cancer+has+a+40-50%+risk+reduction+with+physical+activity+
o Breast+cancer+has+a+30-40%+risk+reduction+with+physical+activity+
• Diet’s+impact+on+health:+food+can+be+your+medicine+
o Diet+is+responsible+for+1/3+of+all+cancer+cases+
o Vegetables+are+key+to+cancer+prevention+
o Obesity+increases+the+risk+of+cancer+
o Carotenoid+(tomatoes,+fruits,+veggies)+intake+can+lower+risks+of+cancer+
o Soy+isoflavones+reduces+inflammation,+improves+bone+health,+reduces+the+risk+of+
some+cancers+(breast,+prostate,+lung)+
o Using+soy+increases+the+sensitivity+of+cancer+cells+to+chemotherapy+and+makes+
non-cancer+cells+stronger,+and+makes+the+chemo+more+effective+while+reducing+
toxicity+
§ How?+Genes+involved+in+cell+growth+are+downregulated,+genes+involved+in+
apoptosis+are+upregulated,+cells+involved+in+DNA+damage+response+are+
upregulated+(for+non-cancer+cells)+
Readings+
Cancer'Prevention'With'Natural'Compounds''
• Reports+of+cancer+chemopreventive+activity+of+dietary+botanicals,+including+cruciferous+
vegetables+such+as+cabbage+and+broccoli,+Allium'vegetables+such+as+garlic+and+onion,+
green+tea,+Citrus'fruits,+soybeans,+tomatoes,+berries,+and+ginger,+as+well+as+medicinal+
plants.+Several+lead+compounds,+such+as+genistein+(from+soybeans),+lycopene+(from+
tomatoes),+brassinin+(from+cruciferous+vegetables),+sulforaphane+(from+asparagus),+
indole-3-carbinol+(from+broccoli),+and+resveratrol+(from+grapes+and+peanuts)+are+in+
preclinical+or+clinical+trials+for+cancer+chemopre-+vention+
• Phytochemicals+have+great+potential+in+cancer+prevention+because+of+their+safety,+low+
cost,+and+oral+bioavailability++
+
