HLTH 210 Lecture Notes - Lecture 4: Headache, Hepatocyte, Myalgia
5 Mar 2018
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Malaria: infectious disease caused by parasite (single-celled prokaryote) Affects liver cells first and then moves to rbcs until parasite des or affected individual dies. To feed on blood for nutrition for babies. About 10,000 years ago, malaria started having a major impact on human survival. Pcr amplification has been found and used to detect plasmodium falciparum. Other malaria strains ar p. vivax, p. ovale, p. knowlesi. Hippocrates: claimed that bad ar caused illnesses. Ge hong: used wormwood extract for medicinal purposes. La mal aria = bad air in italian. One of several cinchona species used for the production of quinine, an anti-fever alkaloid. Especially useful in the prevention of malaria. Identification of parasites in the blood of a patient suffering from malaria, 1880. Momentous discovery that some mosquitoes have malarial parasites in them. Transmission of bird malaria from larks of mosquitoes. Chemists developed new antimalarials, some based on the structure of quinine with similar mechanisms of action.
