PSY 433 Lecture Notes - Lecture 28: Tacrine, Rivastigmine, Hepatotoxicity
29 Jul 2020
Department
Course
Professor
Document Summary
Treating dementia is a challenge for psychiatry and current demencias neurology. Until the early 1980s there were contaba no psychopharmacological treatment that had significant effects on cognitive a os decline. The significant adverse effects of hepatotoxicity it showed ma mejor a significantly importante reduced its chances of use,and motivated a search for new substances capable of enhancing their cognitive enhancement effects without presenting such adverse effects. Donecepyl and rivastigmine are representatives representantes of these drugs and their use has allowed to delay the progression of deterioration in many patients with alzheimer"s dementia. demencia. The anti-demence drugs studied so far have an inhibitory action of acetylcholinesterase, thus producing a reduction of acetylcholine inactivation acetilcolina in synopsis and as a consequence potentiate cholinergic transmission. It is thought that the hippocampus is the place where these substances work the most. The drugs used in the treatment of dependencies have been developed as the prevalence of these disorders has been increased
