PSY 433 Lecture Notes - Lecture 18: Reuptake, Psy, Monoamine Oxidase A
29 Jul 2020
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They reduce the reuptake of norepinephrine and serotonin and block muscarinic histamine and acetylcolic receptors receptores its first action results lugar after repeated administration to a downward regulation of post-synaptic receptors, which is related to its therapeutic action. Its second action is responsible for most parte of its side effects. Selectively inhibit serotonin reuptake; ; lacking in agonist or antagonist activity over other neurotransmitters,which explains the low number of side effects they present It inhibits en non-selective reuptake of serotonin and norepinephrine,and to a lesser degree that of dopamine They irreversibly and non-selectively inhibit selectiva monoamine oxidase (mao), which is an enzyme that metabolizes biogenic amines, such as serotonin, norepinephrine and dopamine. Decreasing their degradation increases the levels of these amines in the synapse Selectively antagonizes presyn ptic alpha-adrenergic receptors and this increases the release of norepinephrine and serotonin receptores it also blocks some serotonergic receptors (5ht 2,and 5ht3),and stimulates.
