GEN-3000 Lecture Notes - Lecture 9: Alpha Helix, Purine, Cytosine
14 Mar 2017
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Document Summary
Known properties of dna: must be capable of being replicated faithfully, must encode and store complex info, must be able to express info to yield phenotype, must have variation as result of mutation. Leavene nucleotide (most basic component of dna) = sugar, phosphate, and base. Also proposed tetranucleotide theory - dna is made up of units of four bases in a fixed sequence - dna too regular to encode information (protein is genetic material) Fred griffith (1928) - transforming principle - early efforts to id. Virulent strain has polysaccharide coat, have smooth coat (s) Coat acts as protection from bacterial cell. Transformation is happening allowing bacteria to change its identity. Kill off one thing at a time. Radioactive proteins did not enter cells and was not transmitted to progeny. Protein not responsible for making new virus. Radioactive nucleic acids was transmitted to progeny. Chargaff and colleagues - isolated dna and found it varied in composition.
