CAS NE 102 Lecture Notes - Lecture 3: Strands If, Chromosome, Phosphodiester Bond
20 Jul 2016
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Ch 6: dna replication and repair: mechanisms that are responsible for copying and maintaining dna with minimal changes, mechanisms that can alter genetic information homologous recombination. Base pairing enables dna replication: each strand serves as a template for a new complimentary strand. Semiconservative: each daughter dna double helix has one parent strand and one newly synthesized strand. Each newly generated strand serves as a template for further replication. In order to copy dna, need to open up double helix. Dna synthesis begun by initiator proteins---bind to replication origin of dna sequence. Proteins pry apart the 2 strands of the double helix. Only 2 h-bonds, g-c have 3 h-bonds (harder to break) Begin replication at many places at once to shorten time of cell to copy genome. Replication forks: form at each replication origin. 2 forks for every replication origin domain. Need high hat activity (histone acetylates---looser chromatin) Dna polymerase synthesizes dna using a parental strand as template.
