CAS BI 315 Lecture Notes - Lecture 3: Phosphorylation, Polysaccharide, Hemoglobin

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A. Hydrogen Bonds
1. Vulnerable to environmental changes
a) Heat
b) Ion concentration
c) pH
B. Solutions
1. Like dissolves like
2. Polar dissolves in solution
3. Nonpolar molecules dissolve in nonpolar solutions
C. Biomolecules
1. Carb - can be structural or metabolic, polar
2. Lipids - supreme energy storage molecules, good cushioning and insulation,
nonpolar
3. Proteins - most diverse and versatile, have polar and nonpolar regions, can be
quite large
4. Nucleic acid - used for storage of info in 4 letter code as well as temporary
storage of energy
D. Glucose
1. Neurons need!!
2. Biologically important monosaccharide
3. Body’s favorite source of energy - why?
a) Respiration??
4. Large polysaccharides are common in biology both as structural elements and
energy storage
5. Humans store excess glucose as glycogen - a complex polysaccharide
E. Lipids
1. Not typical monomer → polymer style
2. Four type - fatty acids, triglycerides, phospholipids and steroids
3. Fatty Acids
a) Single hydrocarbon chain, carboxyl group at one end
b) Can be saturated with H or unsaturated - have fewer H, more double
bonds = kinks so can’t fit
c) Saturated = solid at room temp bc can be packed
4. Steroids
a) Derived from cholesterol
F. Proteins
1. Large, complex, made of AA
a) amino, carboxyl, side chain R
b) Hemoglobin
II. Protein-Ligand Binding
A. Hemoglobin binds Oxygen
B. Oxygen is ligand
C. How strong the binding dependent on shape
D. Protein-Ligand Interactions
1. Affinity - strength and length of interaction
a) dependent on shape and the polarity of parts
2. Saturation
3. Concentration
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