CAS BI 203 Lecture Notes - Lecture 15: Proteasome, Enzyme Inhibitor, Lysine

• School: Boston University
• Department: Biology
• Course: CAS BI 203
• Professor: Francis Monette

Document Summary

T(cid:396)a(cid:374)slatio(cid:374) te(cid:396)(cid:373)i(cid:374)atio(cid:374) (cid:396)e(cid:395)ui(cid:396)es (cid:862)release factors(cid:863: release factors proteins shaped trnas that stop translation and allow the entire ribosome to fall apart. I(cid:374) the (cid:1009)" utr sequence, there is iron response element (ire) found in the. Note: the length of the poly-a tail affects translation. Le(cid:374)gth (cid:272)a(cid:374) (cid:271)e regulated (cid:271)(cid:455) protei(cid:374)s that (cid:271)i(cid:374)d 3" utr (cid:894)(cid:272)a(cid:374) shorte(cid:374) or e(cid:454)tend tail: regulates translational rates, polya regulates translation via pabp which binds eif4g, regulates mrna stability. Remember: rna interference (rnai) can be used to block gene expression references. Ch. 4 regulates translation: synthetic sirnas can be transfected into cells to target mrna of interest, double stranded rna is cleaved by dicer and then associated with risc in order to unwind sirna. The complex then pairs with target mrna and then cleaves it. T(cid:396)a(cid:374)slatio(cid:374) (cid:272)a(cid:374)"t o(cid:272)(cid:272)u(cid:396) (cid:271)e(cid:272)ause of sirnas: eukaryotic genomes contain genes encoding dsrna, which regulate gene expression by.