CAS BI 203 Lecture Notes - Lecture 22: Chek2, Apaf1, Cytochrome C
2 Jan 2017
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11/19/14 4:58:00 pm: apoptosis = programmed cell death, through development born with too many cells get rid of the bad cells o ex. Webs when we are born = remove these cells: protection o if there"s a mutation, then the cell should be gone so it goes through apoptosis. Apoptosis: dna is condensing and fragmenting (into 200 base pairs) fragmentation of nucleus cell starts fragmenting (blebbing, normal cell cell shrinks and chromatin condenses and dna is fragmented into. 200 base pairs membrane blebbing nucleus collapses and cell continues blebbing apoptotic body formation (everything breaks up) lysis of apoptotic bodies (eaten up/removed by the body) Phagocytosis of apoptotic cells: apoptotic cells are recognized by phagocytic cells, characteristics to know it"s an apoptotic cell: o 1. Nucleus/cell will bleb into smaller bodies o 3. Phosphatidlyserine will be exposed on the outside of the cell membrane (membrane flips) allowing phagocytic cells" receptors to recognize cells and lyse them.
