BIOL 311 Lecture Notes - Lecture 12: Radioligand, Stray Light, Amoeba
19 Dec 2016
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Ph ve ry importa nt to this whole s ys te m. Fa milia l hype rchole s te role mia (fh) Due to ge ne tic de fe cts > ca us e d by high le ve ls of ldl. Ma ny type s of de fe cts : Cla s s 1: ldl re ce ptors not s ynthe s ize d to norma l le ve ls. Proble m - a lwa ys a ba s a l le ve l of ldl re ce ptors. Cla s s 2: ldl-r tra ns port. Cla s s 3: proble m with ldl-r binding. Cla s s 4: ldl-r fa ilure to clus te r with ldl. Ie . de fe ct in np xy. Cla s s 5: de fe ct in re cycling. Ca n be e ithe r a nima ls to huma n, or ca n be huma n to a nima l.
