NUSCTX 103 Lecture Notes - Lecture 13: Glut4, Chylomicron, Apolipoprotein E
3 Dec 2020
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Exogenous pathway refers to the metabolism of lipoproteins that contain lipid. Exogenous pathway: packaged to cm, comes out with apo b48 and have cii and e from circulation, can"t go through blood system so goes to lyphatics to heart for entry into general circulation. For this reason, most dietary tag in cms is hydrolyzed in at. We will call the aggregate of receptors that have affinity for cm remnants the remnant receptor: insulin"s role in determining fate of dietary fa in adipose. Insulin secreted in response to a meal: 1, increases lpl on capillaries of adipose, to release fa from cm for fa uptake into adipocytes, 2. Inhibits hormone sensitive lipase activity, limiting ffa release from tag in adipocytes: 3. Increase tag esterification: remember; for cho, insulin stimulated translocation of glut4 transporter to membrane surface to increase glucose uptake. In adipose, insulin promotes fa re-esterification and storage over oxidation. In the fed state, insulin suppresses lipolysis in adipose.
