BIOL-242 Lecture Notes - Lecture 55: Bile Acid, Bilirubin, Cholesterol
16 Jun 2020
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Chapter 24 part 7 | the liver metabolizes, stores, and. Play major role in regulating plasma cholesterol levels. Structural basis of bile salts, steroid hormones, and vitamin d. 15% of blood cholesterol ingested; rest made in body, primarily liver. Lost from body when cetabolized or secreted in bile salts. Part of hedgehog signaling molecule that directs embryonic development. Transport water-insoluble cholesterol and triglycerides in blood. Higher percentage of lipids lower density, hence vldls, ldls, Figure 24. 22 composition of lipoproteins that transport lipids in body fluids. Transport triglycerides from liver to peripheral tissues (mostly adipose) Transport cholesterol to peripheral tissues for membranes, storage, or hormone synthesis. Transport excess cholesterol from peripheral tissues to liver to be broken down and secreted into bile. Total cholesterol = 200 mg/dl or less. Levels > 200 mg/dl linked to atherosclerosis. Form in which cholesterol transported in blood important to measure. High hdl thought to protect against heart disease; >60 good; <40 not good.
