BIOL 4510 Lecture Notes - Lecture 9: Cervical Intraepithelial Neoplasia, Hpv Vaccines, Genital Wart
10 Mar 2018
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New england journal of medicine: foundations of a clinical trial, how important it is to put together an unbiased view. Initial screening: even though the study is randomized, you still have to match the randomization, 11. 8% in the vaccine and 11. 1% showed abnormal pap smear, positive pcr means that you were absolutely excluded. The population with the intention to treat includes all patients, even those with positive: designed study to reduce bias in the study, keep per protocol population as tightly controlled as possible. Hpv-18 related cervical intraepithelial neoplasia grade 2 or 3 and adenocarcinoma in situ. New: use of the nonavalent hpv vaccine in individuals previously fully or partially vaccinated with bivalent or quadrivalent hpv vaccines. Evidence: tumor viruses are not the main cause of cancer: cancer did not spread as infectious disease, no mini-epidemics (ex. Polio, chicken pox: viruses could not be isolated from all tumors.
