BIOL 3210 Lecture Notes - Lecture 22: Acetyl-Coa, Electric Potential, Pyruvate Dehydrogenase
Document Summary
Pyruvate dehydrogenase mechanism and a comparison will be asked. In glycolysis, a few enzymes are named for the reverse reaction. When the phosphate is exchanged, it is a kinase. Another example is succinyl coa catalyzes cleavage od succinate and coa, in the reverse it takes a nucleotide + coa + succinate gets the name synthetase. Shows the three enzymatic steps and the three pathways that use the steps. Phosphates are attached to proteins on hydroxyl groups: amino acids with hydroxyl groups: serine, threonine, tyrosine. Reaction mechanism: ultimately the phosphate is used by gdo t make gtp. Also, the same as complex ii of the etc in mitochondria. Release free energy in a form that can be captured decarboxylation: knock co2 off: alpha-decarboxylation: chopping off the end of a molecule, isocitrate (beta-carboxylation) cut the carbon off in the middle. Nad+ accepts a hydride (two electrons and a proton: typically involved in oxidation reaction like.
