BIOL3190 Lecture Notes - Lecture 7: Growth Factor, Genome-Wide Association Study, Statistical Significance
Document Summary
Investigators look for snps that are linked to a particular trait with statistical significance. Snps are neutral (usually) mile markers: single nucleotide polymorphisms, snps arise by mutation. Dogs are extensively inbred so a lot of their genome is homozygous. 700 dogs: snp 5 most strongly correlated with size- small dogs have the derived form- correlation is strong but not perfect, wanted to see if large dogs had more growth factor in their blood- indeed they did. Gwas studies have identified many correlations, complex traits are usually correlated with multiple genes: schizophrenia- 21 associated snps, 9 chromosomes. Snp microarrays are used for: plant breeding, genealogy, cancer diagnosis. Plants- modern forms have diverged considerably from ancestral forms, but are able to interbreed, they are still members of the same species. Humans have always selected traits that increase yield and nutritional properties: we choose in favor of: Good size and number of seeds and grain.
