BIOL2000 Lecture 15: Lecture 15-Cell Cycle

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Control of the cell cycle: length can vary. Mitosis and s phase doesn"t change in time. Intervals of g1 and g2 can be shortened, lengthened, or eliminated: rate of cell division due to environmental factors. Mitosis-promoting factor: present in the cytoplasm of m-phase cells, induces mitosis in all eukaryotes, structure. Represents a paradigm for the proteins, cyclin b and cdk1 regulation and function. Cdk only active when bound with cyclin: cdk remains constant but cyclin levels oscillates and peaks during the m phase, function. Activated mpf has cyclin and cdk1 and removed phosphates. Initiates nuclear envelope breakdown (phosphorylate nuclear lamins) Activates mitotic spindle (phosphorylates microtubule associated proteins) Related cyclins were discovered for the other cell cycles: cyclin d and cdk4/6 g1 phase, cyclin a and cdk2 s phase, all cdk and cyclin levels are regulated. Friday, april 1, 2016: cyclin-cdk regulation is controlled by. Phosphates also regulate the cyclin-cdk activity: cycle checkpoints.

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