BIOL2000 Lecture Notes - Lecture 18: Cyclic Adenosine Monophosphate, Alternative Splicing, Lac Operon
16 Jan 2017
School
Department
Course
Professor
Document Summary
Control points: alternative splicing of mrnas (unique to euk), altering the rate of transaltion intiation, altering the mrna stability, post trans modification to alter protein abundance, localization or interactions. Instead of multiple reading frames, multiple sequences that will be in final processed rna. Diff exons: different processing to make diff proteins. Spliced different ways: muscle, smooth muscle skeletal. Control splicing by proteins that interact w diff mrnas. Spliceosomes: rna protein complex: carry out splicing. Alt splicing: regulated by proteins that bind to mrnas in nucleus and interact with. Genes: coding and regu sequences that direct production of pp of rnas. Diff forms of gene product: diff domains for diff binding partners. Affects location of protein in the cell. Domains could contain regu sites for post trans modification. Diff forms: diff regu sites: alter activity and localization. Varients: due to diff transcript start sites. Distinct promoters: transcription can be distinct from expression.
