CHE 4341 Lecture Notes - Lecture 5: Arginine, Glutamine, Alpha And Beta Carbon
Document Summary
Enantiomers display optical activity in rotating plane polarized light (mostly l) Have extremely high melting points bc of their ionic nature. Protein = large biological polypeptide (40+ aa long) Along w/vasopressin ( glue hormone ) therefore, causes blood pressure to lower. Tertiary structure = folded 3d structure folding is driven by hydrophobic effect. Polar side chains on outside (can form h-bonds to water) Roles of proteins: (e. g. human dna polymerase beta) Proteins have a hand in the synthesis of every molecule in a living organism. A protein must have correct 3d structure to function if it unfolds (denatures) it loses structure therefore function. Because they"re made out of chiral aa, they have chiral active sites. Thalidomide was a supposed wonder drug prescribed to pregnant women to combat symptoms. The importance of stereochemistry & bioactivity associated w/morning sickness (r-isomer) growth of the fetus resulting in horrid birth defects. When taken during the 1st trimester of pregnancy, thalidomide (s-isomer) prevented the proper.
