CHE 4341 Lecture Notes - Lecture 5: Scrapie, Encephalopathy, Neuron
Document Summary
Proteins that help other proteins in vivo. Many discovered in heat shock > protein unfolds so hsps are made. Hsp70 = dnak in e. coli both surround the unfolded protein. Aggregation is prevented/folding assisted by dnaj & dnak. Both will - coat the unfolded protein. Atp hydrolysis if its" partially folded, protein goes to groel/groes complex: chaperonins. Large chaperones that provide a better place to actively fold proteins. Becomes a barrel once protein goes in. Groes = cap: other enzymes that speed up folding. Catalyses cis-trans isomerisation of peptide bonds involving: protein folding diseases misfolded proteins get proteolyzed immediately, but in some cases, they accumulate as aggregates chronic degenerative diseases affecting the brain & cns. Bse - bovine spongiform encep"thy (mad cow disease) When a soluble protein w/a mostly -helix conformation misfolds into a precipitating -sheet conformation. The infection involves a of 2 structure & conformation in the pathogenic protein. *the misfolded -sheet conformations can encourage more misfolds*
