PHIL 2015 Lecture Notes - Lecture 58: Dna-Binding Domain, Hormone Response Element, Zinc Finger
23 May 2020
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Document Summary
Nuclear receptors are transcription factor s - act to regulate mrna levels by controlling gene transcription 1. Receptor must be activated, which usually involves binding by a specific small molecule hormone ligand 2. Receptor must undergo a conformational change as a result of ligand binding and dna binding, enabling it to activate transcription 3. Receptor usually binds to a specific dna sequence, termed a hormone response element (hre)-review nursa if have time. As such, there can be many mrna expression patterns with hundreds of genes as a consequence of nuclear activation. The nuclear receptor binding sites are not all close to the transcription start site. There is transcription factor hot spot upstream of where transcription starts. Nuclear receptors are modular-some domains overlap in function though. There"s a ligand binding domain, which can dimerize in some cases and can interact with cofactors. It has aa residues that participate in homo and heterodimerization of receptors.
