PHIL 2015 Lecture Notes - Lecture 56: G0 Phase, Oncogene, Glioblastoma Multiforme
23 May 2020
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Document Summary
Dna is replicated, cell will double check again to make sure no damage done to replication before cell undergoes mitosis and again p53 is important in controlling this checkpoint. Cyclins and cdks and cyclinc cdk complex are important in phosphorylating many proteins throughout cell cycle to regulate their function, one important protein you phosphorylate is rb to control function of rb. 2/neu receptors is increased in these patients and cells can proliferate much faster, there is a drug that can block these receptors, called herceptin. Oncogenes induce autonomous proliferation as well as can from production a mutant receptor which is always activated like patients with ret mutations so syndromes of. Men, multiple endocrine neoplasia syndrome, so have lots of thyroid cancers, adrenal glands, parathyroid cancers as well as c-kit mutation so gastrointestinal stromal tumors, mutated c-kit gene and again drug that can target these c-kit receptors. Another way that oncogenes can do this is produce mutated signal-transducing proteins.
