KINE 2475 Lecture Notes - Lecture 18: Polydipsia, Chemotherapy, Legionella

• School: York University
• Department: Kinesiology & Health Science
• Course: KINE 2475
• Professor: Dave Chambers

Document Summary

Sudden decrease in renal function secondary to decreased blood flow to kidney. Also called acute renal failure (<3 months duration) Causes build of waste in blood (creatinine), fluid and electrolyte imbalance. Can be reversible if caught early and the cause is treated quickly. S/s of aki: systemic features (pulmonary involvement, joint involvement, rashes, neurologic features), htn, abnormal urine sediment (presence of rbcs, wbcs, or protein, cellular casts) S/s: tachycardia, orthostatic changes in bp, heart rate. Effective circulating volume cardiac output (heart failure) and liver failure. Intrarenal damage to nephrons: decreased ability to filter blood, remove waste and excessive water, maintain electrolyte levels, classifications, glomerular, primary (idiopathic) secondary (autoimmune disease, malignancy, infection hiv, hepatitis b/c, drugs/toxins nsaids, lithium, heroin, other) Interstitial inflammation resulting in aki: causes: drugs (nsaids, antibiotics, penicillin, cephalosporins, fluoroquinolones, rifampin, sulfonamides, ppis, allopurinol), autoimmune disease (sarcoidosis, Sjorgren"s disease), infections (bacterial legionella, mycoplasma, viral ebv,