KINE 2011 Lecture Notes - Lecture 21: Atherosclerosis, Factor Viii, Thrombus
17 Sep 2017
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Two main pathways of clotting: intrinsic clotting pathway (good at small little internal damages). It is called because everything we need is already there. If there"s damage to blood vessel surface, the exposure to collagen is going to activates factor 12, which activates he rest, eventually activating thrombin, eventually converting fibrinogen to fibrin to get the mesh network. Set off when factor xii (hageman factor) is activated by exposed collagen. All factors necessary are in blood: extrinsic pathway: damaged entire vessel, blood is beginning to leave *tissue damage, tissue produced tissue thromboplastin, which can activate factor 10, skipping all these steps, which converts fibronen into the mesh network. Just because we skip, we still get slow steps but we start further ahead. One problem is tissue thromboplastin is produced by traumatized tissue, so for crush injuries, you may end up getting a clotting response even when there"s not a damaged vessel. Shortcut only 4 steps (more serious)
