KINE 1020 Lecture Notes - Lecture 22: Endothelial Dysfunction, Endothelium, Coagulation
8 Dec 2017
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Document Summary
Heart disease - caused by how much stress is on the heart and how much work it has to. If you have high load and low energy, you are setting heart up for big problems do to overcome that stress. Load on heart = what is making the heart work/preventing it from working to full capacity. Energy = how strong the heart is, how well it can contract. Inflammation or infection in the heart can prevent is to be a a is heart from squeezing and very dangerous can die from this. These are chemicals released from the immune system and from fat cells. So, the more fat you have, the higher the levels of the pro-inflammatory chemicals you have and they damage tissue. Also, some stress hormones (norepinephrine, epinephrine, angiotensin) become elevated ---- all these things working together eventually causes a failing heart - failing heart = a heart that cannot produce enough blood flow for the working body.
