CHEM 3050 Lecture Notes - Lecture 7: Pyruvate Dehydrogenase, Acetyl-Coa, Citric Acid
2 May 2018
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CHEM 3050
Lecture 7
Advantages of Pyruvate dehydrogenase multienzyme Complex:
Product release close to next active site
Coordinated control
Turn up turn down is all coordinated, nothing is waiting on
anything else
Hydroxyethyl dehydrogenase is an intermediate (covalent
resonant stabilized intermediate)
Allows the decarboxylation of pyruvate to make acetyl-CoA and
does this in a very coordinated fashion
Step 1: Making Citrate… via citrate synthase
Citrate is made from acetyl CoA and oxaloacetate e feeds in
from the ‘end’ of the cycle
2 his in catalytic site to coordinate this at neutral pH
Asp pulls off proton
Step2: Making Iso-Citrate…via Aconitase
This sets up reduction of NAD+
Uses a catalytic Iron/Sulphur cluster (4Fe~4S) (cofactor)
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