CHEM 3050 Lecture Notes - Lecture 19: Pyruvate Dehydrogenase, Acetyl-Coa, Isocitric Acid
2 May 2018
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CHEM 3050
Lecture 19
Advantages of Pyruvate dehydrogenase multienzyme
Complex:
o Product release close to next active site
o Coordinated control
▪ Turn up turn down is all coordinated,
nothing is waiting on anything else
▪ Hydroxyethyl dehydrogenase is an
intermediate (covalent resonant stabilized
intermediate)
▪ Allows the decarboxylation of pyruvate to
make acetyl-CoA and does this in a very
coordinated fashion
Step 1: Making Citrate… via citrate synthase
- Citrate is made from acetyl CoA and oxaloacetate
e feeds in from the ‘end’ of the cycle
o 2 his in catalytic site to coordinate this at neutral
pH
o Asp pulls off proton
Step2: Making Iso-Citrate…via Aconitase
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