KP222 Lecture Notes - Lecture 11: Skeletal Muscle, Intercalated Disc, Resting Potential
Lecture 11:
Muscle
Length Tension Graph
Unit 3: Cardiac
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Document Summary
Gap junctions: skeletal muscles are not connected, cardiac are connected. Do not use recruitment in cardiac muscle. Regular cardiac muscle cells: connected so if the one has a action potential then it will go to the other. Wave of cardiac muscle contractions in a uniform direction. Does it due to gap junctions (allows for communication) and current of positive charge (sodium and calcium) and go from one cell to the next. Intercalated disc: whole region of connections, gap junctions, structural desmosomes that hold the muscles together. Need the rate of depolarization so it will start at the bottom and move upward because the exit of the ventricles is at the top. Will contract and squeezing blood through to the ventricles. Will get cell depolarization through gap junctions. They inactivate in conformational change and close: funny channels. Open up and close up immediately (around -55mv: opening of calcium channels (t-type channels, l-type ca2+ channel.
