HE440 Lecture Notes - Lecture 17: Insulin-Like Growth Factor 1, Adiponectin, Arsenic
Document Summary
Num ber(cid:9)of(cid:9)cancer(cid:9)cases(cid:9)in(cid:9)2012,(cid:9)am ong(cid:9)m en(cid:9)and(cid:9)wom en(cid:9)of(cid:9)all(cid:9)ages(cid:9)(30+ (cid:9)years),(cid:9)attributable(cid:9) to(cid:9)ultraviolet(cid:9)(uv)(cid:9)radiation(cid:9)exposure,(cid:9)by(cid:9)continent s e s a (cid:9)c e l b a t u b i r t t f (cid:9)a (cid:9)o r e b m u. Africa s e s a (cid:9)c e l b a t u b i r t t f (cid:9)a (cid:9)o r e b m u. Gr aph(cid:9)pr oduction:(cid:9)global(cid:9)cancer (cid:9)obs er vator y(cid:9)(http://gco. iar c. fr /) Arsenic egfr: arsenic exposure can induce phosphorylation of egfr, likely activates the kinase, cyclin d1 is the final target of egfr signaling induced by arsenic, transcription factors fos and jun are upregulated in response to arsenic exposure. Induces mapk signaling pathway (raf1, mek1/2, jnk1/2, p38) Induce mmp7/9: liver cancer patients in an endemic area of arsenic intoxication showed higher serum egfr levels compared to other patients, egfr may be a biomarker for arsenic exposure. Sam as a methyl donor group, interferes with methyl groups required by cellular processes.
