CH202 Lecture 11: Ch202 lecture 11
Document Summary
Weight: heavier = more drug needed. Body fat content: more fat = more drug (absorption) Body water content: more water = more drug (dilution) - sex, men typically need more than women (men have more enzymes that break down the drugs) Age: very young possibly entirely different neuropharmacology o very old possibly unpredictable drug effects. Genetics: e. g. about 10% of asians cannot metabolize alcohol; 40% do so poorly (get flushed, nauseous after maybe 1 or 2 drinks) Irrespective of the method of drug delivery, drugs must reach the bloodstream to be effective. In the case of psychoactive drugs, they must reach the brain. Oral administration go to stomach (20-30 minutes), then bloodstream goes to liver, then right side of heart, lungs, left side of heart, then brain. Inhalation goes to lungs, then left side of heart, then brain. Iv right side of heart, lungs, left side of heart, brain.
