BI236 Lecture Notes - Lecture 13: Nuclear Membrane, Plectin, Mhc Multimer
Document Summary
Microtubules > intermediate laments > micro laments (largest to smallest) Detergents remove mt, mf other proteins and leave networks of if that retain shape. Ifs are important structural determinants in many cells and tissues; they are thought to have a tension-bearing role. Ifs are not static structure; they are dynamically transported and remodelled. The nuclear amino (class v) on the inner surface of the nuclear envelope, disposables at the onset of mitosis and reassemble afterward. Ifs, mts, and mfs interconnected to form mechanically integrated network. Mts > resist bending during cell compression. Ifs > elastic, withstand large tensile forces. Epithelial cells that line intestinal walls subjected to large compressions by smooth muscles. Linker proteins that connect ifs, mfs, and mts. Skin to be very fragile and to blister easily. Blistering skin can be caused by a mutant keratin gene: Rupturing of cells in basal layer of mutant epidermis. Between nucleus and hemidesmosos > connect keratin laments to underlying basal lamina.
