BI236 Lecture Notes - Lecture 34: Nuclear Lamina, Nuclear Membrane, Plectin
Document Summary
Ifs are important structural determinants in many cells and tissues; they are thought to have a tension-bearing role. Ifs are not static structures; they are dynamically transported and remodeled: the nuclear lamina (class v), on the inner surface of the nuclear envelope, disassemble at the onset of mitosis and reassemble afterward. Ifs, mts, and mfs interconnect to form mechanically integrated network: mechanical properties, mts resist bending during cell compression, mfs contractile elements that generate tension. Ifs elastic, withstand large tensile forces: stress-bearing properties of cytoskeleton. Epithelial cells that line intestinal walls subjected to large compressions by smooth muscles. The cytoskeleton is a mechanically integrated structure: plakin family linker proteins that connect ifs, mfs, & mts, plectin, cross-linking protein links ifs to mts & mfs. Epidermolysis bullosa simplex (ebs: hereditary blistering skin disease: keratin mutation skin to be very fragile and to blister easily.
