BI236 Lecture 9: BI236 Week 3 - DNA Transcription II - Winter 2019
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The TATA-binding protein (TBP) binds to the TATA box sequence in eukaryotic promoters. What is its function in transcriptional initiation?
It blocks access of RNA polymerase to the promoter, until removed by general transcription factors.
It is the subunit of prokaryotic RNA polymerase that is required to recognize promoters.
It modifies histones so nucleosomes can be removed from DNA for transcription.
It bends and partly unwinds DNA at a promoter.
The genetic code is said to be âdegenerateâ because
there are more codons than amino acids. |
there are more amino acids than codons. |
different organisms use different codons to encode the same amino acid. |
some codons specify more than one amino acid. |
Three general mechanisms appear to be responsible for the conversion of proto-oncogenes to oncogenes
overexpression, point mutations, deletions |
inversions, translocations, methylation |
familial, sporatic, phosphorylation |
None of the above account for the conversion of proto-oncogenes into oncogenes |
Transcriptional control of genes that acts by regulating the continuation of transcription is called
induction |
attenuation |
antitermination |
negative inducible control |
The genetic code is fairly consistent among all organisms. The term used to describe this consistency is
redundant |
resilient |
universal |
the central dogma |
The F, G, and H loci are linked in the order written. There are 30 cM between F and G and 30 cM between G and H. If a plant Ff Gg Hh is testcrossed, what proportion of the progeny will be ff gg hh, assuming no interference?
0.7 |
0.3 |
0.245 |
0.15 |
DNA synthesis is always from 5â to 3â because
replication must be continuous |
the strands are antiparallel |
primers lack 3â to 5â exonuclease activity |
none of the above |
The F, G, and H loci are linked in the order written. There are 30 cM between F and G and 30 cM between G and H. If a plant Ff Gg Hh is testcrossed, what proportion of the progeny will be ff gg hh, assuming no interference?
0.7 |
0.3 |
0.245 |
0.15 |
In the ZZ-ZW sex-determination system, if an AaBb female was crossed to an individual of genotype Aa Bb, what is the probability of a female offspring with the two dominant traits given by alleles A and B? Assume A and B are dominant alleles.
1/8 |
1/16 |
9/16 |
9/32 |
1. | In addition to identifying the genetic material, the experiments of Avery, MacLeod, and McCarty with different strains of Streptococcus pneumoniae demonstrated that | ||||||||||
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2. | In order to show that DNA in cell extracts is responsible for genetic transformation in Streptococcus pneumoniae, important corroborating evidence should indicate that _______ also destroy transforming activity. | ||||||||||
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3. | Based on what you have learned about the experiments conducted by Griffith and Avery and colleagues with bacteria, which of the following would result in transformation of living R cells? | ||||||||||
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4. | A-T base pairs in a DNA double helix | ||||||||||
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5. | If 23 percent of the bases in a sample of double-stranded DNA are adenine, what percentage of the bases are uracil? | ||||||||||
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6. | The uniform diameter of the DNA structure provides evidence for | ||||||||||
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7. | If a sequence of one strand of DNA is 5â²-TGACTATC-3â², what is the complementary strand? | ||||||||||
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8. | What structural aspect of the DNA facilitates dissociation of the two DNA strands for replication? | ||||||||||
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9. | If the MeselsonâStahl density gradient experiment had resulted in two bands of DNA molecules after only one round of replication, one containing only 15N and the second only 14N, this result would have indicated that replication was | ||||||||||
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10. | The nucleoside analogue acyclovir, which is used to treat herpes simplex virus (HSV) infections, lacks a 3â² hydroxyl group (âOH). Predict what will happen if the host cell DNA polymerase incorporates a molecule of acyclovir into an elongating strand of HSV DNA. | ||||||||||
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11. | Which of the following does not demonstrate the stability of the DNA double helix? | ||||||||||
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12. | What effect would a primase inhibitor have on DNA replication? | ||||||||||
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13. | To replicate their DNA in a timely manner, most eukaryotic chromosomes | ||||||||||
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14. | Which statement about DNA replication is false? | ||||||||||
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15. | In many eukaryotes, there are repetitive sequences called telomeres at the ends of chromosomes. After successive rounds of DNA replication, the _______ strand becomes shorter. In some cells, an enzyme called _______ repairs the shortened strand. | ||||||||||
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16. | A researcher studies normal human fibroblast cells. They can be maintained in culture but die off after about 30 cell generations. Unexpectedly, a colony of cells continues to survive and divide past 30 generations. Which scenario is most likely true for these cells? | ||||||||||
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17. | If DNA polymerase III introduces an incorrect nucleotide, what is the first corrective action made by the DNA repair system? | ||||||||||
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18. | Choose the correct order of the following four events in the excision repair of DNA: (1) Base-paired DNA is made complementary to the template. (2) Damaged bases are recognized. (3) DNA ligase seals the new strand to existing DNA. (4) Part of a single strand is excised. | ||||||||||
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19. | Six complete cycles of PCR should result in a _______-fold increase in the amount of DNA. | ||||||||||
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20. | When double-stranded DNA is heated to temperatures above 90°C, it denatures. Denaturation is a process that | ||||||||||
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