BI236 Lecture Notes - Lecture 1: Tata Box, Transcription Factor Ii D, Protein Kinase
Document Summary
General transcription factor: required to bind to its promoter and initiate rna synthesis, eukaryotes have many different transcription factors, thei(cid:396) (cid:374)a(cid:373)es i(cid:374)(cid:272)lude (cid:858)tf(cid:859) (cid:894)tfiia, tfiib et(cid:272). (cid:895) Elongation, termination, and rna cleavage in eukaryotic rna synthesis. Special proteins facilitate the disassembly of nucleosomes in front of the moving polymerase and their immediate assembly after the enzyme passes. If there is a dna damage, rna polymerase becomes stalled temporarily during. Dna excision repair: termination is governed by a set of signals that differ for each type of rna polymerase, rna polymerase i: Terminated by a protein factor that recognizes an 18-nt termination signal in the growing rna chain: rna polymerase iii: Termination signals include a short run of u"s (as in bacterial termination signals), and no proteins are required for their recognition: termination in rna polymerase ii. Mrnas are cleaved at a specific site, a cleavage site, before transcription is actually terminated.
