BI110 Lecture Notes - Lecture 37: Contact Inhibition, Telomere, Nuclear Membrane
Document Summary
Cell cycle is controlled by complexes of cyclins together with cyclin-dependent protein kinases (cdks) Only activated when combined with the cyclin. Several different cdks and cyclins can combine in different combinations and regulate transitions at different checkpoints . Cells that do not divide do not pass g1 checkpoint. Once passed g1, cell is usually committed to complete mitosis. Cells with dna or chromosome damage will fail to pass g2 and m checkpoints. M checkpoint is only passed once spindle is attached to kinetochore. Different cyclins become more and more abundant at particular stages so they can bind to their. Maturation/mitosis-promoting factor (mpf) is a cyclin-cdk complex that participates in enzyme activation, nuclear envelope breakdown and chromosome condensation. S phase is where the cell synthesizes dna. Ensures that reactions at one stage are complete before moving onto the next stage. These factors alter the activity of the cyclin:cdk complexes. Based on surface receptors that recognize and bind signals.
