BI110 Lecture Notes - Lecture 25: Cholesterol, Cytoskeleton, Fluid Mosaic Model

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21 Dec 2015
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Importance: cells and organelles need barrier to separate internal and, barrier must have following qualities external contents. Insoluble in water (so that they don"t dissolve) Permeable to water (cells need to allow water in and out; water can and must get into a cell: controls contents of the cell, most important structure in regards to sensing the environment. Primary molecules that make up biological membranes. Carbohydrates are located on extracellular side of membrane (not found inside/cytoplasmic side) Not homogenous/random arrangement of lipids and proteins that make up a membrane: sterols (except in bacteria) Aside from the phospholipids being important for cell membrane structure, proteins are most important to a cell/cell membrane: membrane proteins. Integral proteins (usually transmembrane; embedded in/run through membrane) Amphipathic, containing both hydrophobic and hydrophilic amino acid: hydrophobic domains in the trans- membrane region of an integral membrane protein stabilize it within the lipid bilayer. Peripheral membrane proteins (sit on outside of the membrane)

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